Vaccinia virus (Bert Jacobs)

M20-215L: A SARS-CoV-2 vaccine using recombinant attenuated poxvirus vectors that express SARS-CoV-2 antigens to stimulate a protective systemic and mucosal immunity. The vector has been modified to possess increased immunogenicity.

Human embryonic kidney cells (Brenda Hogue)

M20-216L: Mammalian-cell-produced virus like particles (VLPs) as SARS-CoV-2 or other coronavirus vaccines that could elicit a robust systemic and mucosal immune response.

Plants (Qiang “Shawn” Chen)

M20-217L: Plant-produced chimeric Hepatitis B core-based virus like particles (VLPs) and recombinant immune complexes (RIC) vaccines for SARS-CoV-2 that could elicit a potent and neutralizing immune response.

Myxoma virus (Grant McFadden)

M20-234L: Vaccine based on myxoma virus expressing SARS-CoV-2 antigens. The virus vector could also be used to transfect mammalian cells for the production of SARS-CoV-2 virus like particles (VLPs) for use as vaccine compositions.

Prediction algorithm for identifying immunogenic peptides for use in COVID-19 vaccine development (Karen Anderson)

M20-278L: Integrated algorithm for predicting T-cell epitopes and the development of compounds, using such data, for therapeutics. A polypeptide T-cell vaccine composition targeting SARS-CoV-2 was developed with this algorithm.

COVID-19 testing service and data management software (Michael Fiacco)

M20-274L: Automated Testing Service Software (TSS) that accurately and securely manages the complex data required for high throughput COVID-19 diagnostic testing. This software includes a participant portal, administrative portal, test result interpretation and quality control module, and a results report delivery module. Facilitates delivery of test results in less than 24-48 hours.

COVID-19 testing service and data management software (Michael Fiacco)

M20-275L: COVID-19 Testing Data Management System (TDMS) architecture that supports multi-faceted complex data management tasks for the Testing Services Software (TSS). The TDMS streamlines COVID-19 diagnostic testing workflow.

Machine-learning to generate COVID-19 social distancing and self-quarantine guidelines (Sandeep Gupta)

M20-244P: A mobile COVID-19 assessment application that monitors at-home symptom progression and shares that data with a care provider to determine best treatment options. The data may also be shared with the research community to help estimate potential spread and availability of medical supplies or PPE.

RNA-origami-based COVID-19 therapeutic (Hao Yan/Yung Chang)

M20-272L: Programmable RNA-origami nanostructures for rationally designed immunotherapeutics and vaccines against SARS-CoV-2; such structures could be used to block virus entry into host cells and induce robust immunity against future infections.

Compounds to modulate retinoid X receptors (Carl Wagner)

M19-109L & Others: A portfolio of potent analogs and derivatives of Bexarotene, CD3254, LGD100268 and Tamibarotene with improved PK and triglyceride profiles, which recent research suggests may have potential to treat COVID-19. Bexarotene (the parent compound) demonstrated a higher Cmax:EC50 ratio than chloroquine, hydroxychloroquine and ivermectin.

Automated system for monitoring and regulating aerosols and microparticles (Erica Forzani)

M20-306L: Technology for sensing and controlling aerosols and microparticles in closed environments in a safe, automated, and energy efficient manner to decrease the risk of disease transmission. When the technology detects aerosols and microparticles at a level that exceeds a specified threshold, it triggers visual/audible warning signals and automatically reacts by increasing the air exchange rate of the room.

Face mask for decreasing aerosols generated during respiratory therapies (Erica Forzani)

M20-305L: Face-mask technology that filters aerosols emitted from a potential contaminated source, such as a COVID-19 patient undergoing nebulization, nasal cannula, ventilator, or other respiratory treatments. The technology achieves dramatically better aerosol-mitigation efficiency than currently available technologies.

Self-cleaning facial mask against airborne pathogens (Morteza Abbaszadegan)

M20-253L: Novel, chemical-free device for use with face masks or other PPE that inactivates viruses and bacteria to minimize exposure to airborne pathogens.

Low-cost sterilization technologies using ozone & vaporized hydrogen peroxide (ASU Luminosity Lab)

M20-259L: Low-cost modular ozone generator which generates ozone from atmospheric air for the disinfection and sterilization of medical supplies/equipment, PPE, clothing, rooms, public areas and other items.

Disinfection and sterilization of medical supplies/equipment (ASU Luminosity Lab)

M20-260L: Portable, rapid, vaporized hydrogen peroxide treatment system for the disinfection and sterilization of medical supplies/equipment, PPE and more. This system avoids the risk of explosive or violent decomposition of hydrogen peroxide.

Rapid-manufacturable, 3D-printed, filter-enabled face mask (ASU Luminosity Lab)

M20-287P: 3D-printed face mask optimized for rapid manufacturability. The mask includes a silicone sealing mechanism and is filter-enabled. This mask was created specifically to address N95-mask shortages among medical professionals and first responders.

Rapid UV-C sterilization system for personal protective equipment (PPE) (Paul Westerhoff)

M19-070P: Low-cost, portable UV sterilization technology similar in size to a portable barbeque grill.

Rational design for viral diagnostics optimization (Alexander Green)

M20-303L: Paper-based point-of-care diagnostics platform for rapid, low-cost and efficient pathogen detection, including SARS-CoV-2. This platform reduces false negatives, increases assay specificity and sensitivity and is able to be used in broader and more diverse care settings.

Point-of-need diagnostic with thermal control (Jennifer Blain Christen)

M20-286L: A point-of-care diagnostic with internal thermal control for PCR or other thermally controlled processes, to enable rapid screening of large populations; the system utilizes disposable cartridges to retain electronics without contamination.

Sensitive detection of viral infections (Shengxi Chen)

M19-272L/M17-250L: Platform for rapid and cost-effective detection of viral infections, including possibly SARS-CoV-2. The platform uses a novel tandem toehold-mediated displacement reaction to form an amplifying loop and enhance the fluorescence signal for extremely sensitive detection.