There is a rich history of successful drug delivery carriers made of biodegradable biomaterials. Biomaterials may degrade into metabolic by-products, which are capable of modulating the function of immune cells, including alpha-ketoglutarate (aKG), which induces alternative activation (immunosuppressive phenotype) in macrophages through metabolic reprogramming. However, delivery of aKG to modulate the metabolism of immune cells is non-trivial, as this molecule gets metabolized quickly, diffuses away from the injection site, and therefore needs to be provided via multiple injections. Thus, there is a need for improved methods of delivery of therapeutic agents (e.g., aKG) for tissue regeneration and/or treatment of diseases or disorders.
Researchers at Arizona State University have developed a cutting-edge approach utilizing specially designed polymers and particles for the delivery of therapeutic agents, such as α-ketoglutarate, directly to cells. This method aims to improve biological tissue growth and wound healing by controlling the release of metabolites within the cellular environment, thereby modulating immune responses and promoting regenerative processes.
Potential Applications
- Regenerative medicine and wound repair
- Targeted and controlled release of therapeutic agents
Benefits and Advantages
- Biodegradable, polymer degrades to release components in a slow and sustained manner that leads to accelerated healing
- Non-reactive i.e., does not cause adverse reactions in vivo
- Flexibility in administration routes including oral, topical, and intravenous
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