Excessive synchronization of populations of neurons has been implicated in several neurological conditions. Coordinated reset neuromodulation, is a method which takes advantage of neuroplasticity to counteract excessive synchronization and reset the phase and change connection strengths of neurons. As such, it may be used to treat these neurological conditions such as epileptic seizures, Spasmodic Dysphonia, Parkinson’s Disease and Tourette’s syndrome. Many of these neurological conditions are conventionally treated with Botox injections, vibrotactile devices or oral medication, which typically do not provide long lasting effects.
Researchers at Arizona State University in collaboration with researchers and clinicians at the Mayo Clinic have developed an implantable electrode neuromodulation system for the treatment of a number of neurological conditions. This device utilizes the concept of coordinated reset to desynchronize neuronal activity. The electrode is designed with materials that minimize abrasions to the nerves, extending the life of the treatment. Material characterization testing was completed through impedance spectroscopy and cyclic voltammetry to ensure efficacy and safety.
This system holds potential as an innovative treatment option for many neurological conditions, offering an alternative and longer lasting approach to conventional treatments like Botox injections.
Potential Applications
- Coordinated reset neuromodulation
- Laryngeal nerve stimulation for spasmodic dysphonia treatment
- Treatment of Parkinson’s disease
- Treatment of epileptic seizures
- Treatment for Tourette’s syndrome
Benefits and Advantages
- Long term treatment option
- Reduced treatment frequency
- May have sustained therapeutic effects
- Utilizes materials with reduced nerve abrasion
- May cost less overall compared to more frequent treatment options
- This type of neuromodulation typically does not require extensive calibration
For more information about the inventor(s) and their research, please see