Case ID: M13-142LC^

Published: 2020-02-26 11:08:14

Last Updated: 1677135133


Sidney Hecht
Manikandadas Mathilakathu Madathil
Chandrabali Bhattacharya
Trevor Bozeman
Rakesh Paul
Zhiqiang Yu
Michael Rishel

Technology categories

ImagingLife Science (All LS Techs)Medical ImagingPharmaceuticals

Technology keywords

Drug Target Identification
Medical Devices and Imaging
Molecular Diagnostics

Licensing Contacts

Jovan Heusser
Director of Licensing and Business Development
[email protected]

Optimized Carbohydrates for Tumor Targeting

The bleomycins (BLMs) are well-known antineoplastic agents, clinically useful in the treatment of squamous cell carcinomas and malignant lymphomas. The carbohydrate moiety, particularly the disaccharide moiety, of BLM is also known to be highly tumor targeting.

Researchers at the Biodesign Institute of Arizona State University have discovered disaccharides that target tumor cells more efficiently than the natural BLM disaccharide. Numerous highly specific disaccharide analogues have been produced and conjugated to an imaging agent or a reporter group. These disaccharides have been tested in several cancer cell lines including prostate carcinoma cells and showed excellent tumor targeting.

These novel disaccharide analogs with their high specificity for tumors offer great utility as tumor imaging agents.

Potential Applications

  • Tumor imaging agents

Benefits and Advantages

  • More efficient tumor targeting than the disaccharide moiety of BLM

For more information about the inventor(s) and their research, please see
Dr. Hecht’s departmental webpage